Disposition of single oral doses of butylated hydroxytoluene
The kinetics and metabolism of butylated hydroxytoluene (BHT) in man and rats have been compared. Single oral doses of 200, 63 or 20 mg BHT/kg body weight were administered to rats and a single oral dose of 0.5 mg/kg body weight was ingested by human volunteers (non-smoking males).
Disposition of single oral doses of butylated hydroxyanisole
The kinetics and metabolism of butylated hydroxyanisole (BHA) have been compared between man and rats. Oral doses of 2, 20 or 200 mg BHA/kg body weight were administered to male Wistar rats and a single oral dose of 0.5 mg/kg body weight was administered to human volunteers (non-smoking males).
Butylated Hydroxytoluene - The Cosmetic Chemist
Butylated hydroxytoluene (BHT) is commonly used in cosmetic formulations as an antioxidant. In addition to personal care products and makeup, it is also widely used in plastics and foods. BHT (or 2,6-di- tert -butyl- p -cresol) is a white to yellowish crystalline solid that prevents the oxidation of fats and oils, and helps to extend a product
Butylated Hydroxytoluene (BHT) In Food - Uses, Safety, Toxicity
In two men, excretion of a single oral dose of 40 mg/kg [14C] butylated hydroxytoluene (BHT) was 50% in the first 24 hours, followed by slower excretion for the next 10 days. In total, 63-67% of the dose was excreted in the urine after 10 days.
Pharmacokinetics of a novel butylated hydroxytoluene
Mice, rats, dogs, and monkeys were given a single 50 mg/kg oral dose of [14C]LY256548. Plasma levels of radioactivity and LY256548 were determined, as was the excretion of radioactivity. Peak plasma levels of LY256548 occurred prior to those of radioactivity in mice, dogs, and monkeys, but were coincident in rats. The Cmax of LY256548 in rats, mice, dogs, and monkeys was 0.17, 0.30, 0.04, and
Provisional Peer-Reviewed Toxicity Values for Butylated
1 Butylated Hydroxytoluene . PROVISIONAL PEER-REVIEWED TOXICITY VALUES FOR BUTYLATED HYDROXYTOLUENE (CASRN 128-37-0) BACKGROUND . A Provisional Peer-Reviewed Toxicity Value (PPRTV) is defined as a toxicity value derived for use in the Superfund Program. PPRTVs are derived after a review of the relevant
707. Butylated hydroxytoluene (BHT) (WHO Food Additives
The disposition of single oral doses of BHT was compared in man and rat. A single oral dose of 0.5 mg/kg body weight of BHT was ingested by 7 healthy male volunteers after fasting overnight. Blood samples were taken after 0, 15, 30, 45, 60, 75, 90, 120, 150, 180 and 240 minutes. Total urine and faeces were collected for 2 days.
The metabolism of 2,6-di-tert.-butyl-4-hydroxymethylphenol
Abstract. 1. A single oral dose of [14 C]Ionox 100 to rats is almost entirely eliminated in 11 days: 89·1–107·2% of the 14 C is excreted and 0·29±0·02% of the dose is present in the carcass plus viscera after removal of the gut.
Butylated Hydroxytoluene (BHT) (IARC Summary & Evaluation
In mice, a single intraperitoneal dose or feeding of butylated hydroxytoluene can cause pulmonary alveolar cell necrosis and proliferation. Butylated hydroxytoluene also induces proliferation of smooth endoplasmic reticulum in rat-liver cells, leading to hepatomegaly.
SAFETY DATA SHEET BHT - Sasol
Chemical Name LD50 Oral LD50 Dermal LC50 Inhalation Butylated Hydroxytoluene >6,000 mg/kg (Rat) >2000 mg/kg (Rat) Chronic toxicity Repeated dose toxicity Repeated oral exposure of laboratory animals (rats and mice) at doses greater than 25 mg/kg/day resulted in growth depression and functional and histological
Quantitative identification of and exposure to synthetic
Disposition of single oral doses of butylated hydroxytoluene in man and rat Single oral doses of 200, 63 or 20 mg BHT/kg body weight were administered to rats and a single oral dose of 0.5 mg
The urinary excretion of tritiated butylated hydroxyanisole
Disposition of single oral doses of butylated hydroxytoluene in man and rat. Verhagen H, Beckers HH, Comuth PA, Maas LM, ten Hoor F, Henderson PT, Kleinjans JC. Food Chem Toxicol, 27(12):765-772, 01 Dec 1989 Cited by: 6 articles | PMID: 2606406
Gastric retention and delayed absorption of a large dose
1. After a single oral dose of 800 mg/kg of butylated hydroxytoluene to rats, the plasma concentration of 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone (BHT quinone methide), an active metabolite of BHT, reached a maximum 18 h after dosing.