• disposition of single oral doses of butylated hydroxytoluene

    Disposition of single oral doses of butylated hydroxytoluene

    The kinetics and metabolism of butylated hydroxytoluene (BHT) in man and rats have been compared. Single oral doses of 200, 63 or 20 mg BHT/kg body weight were administered to rats and a single oral dose of 0.5 mg/kg body weight was ingested by human volunteers (non-smoking males).

  • disposition of single oral doses of butylated hydroxyanisole

    Disposition of single oral doses of butylated hydroxyanisole

    The kinetics and metabolism of butylated hydroxyanisole (BHA) have been compared between man and rats. Oral doses of 2, 20 or 200 mg BHA/kg body weight were administered to male Wistar rats and a single oral dose of 0.5 mg/kg body weight was administered to human volunteers (non-smoking males).

  • butylated hydroxytoluene - the cosmetic chemist

    Butylated Hydroxytoluene - The Cosmetic Chemist

    Butylated hydroxytoluene (BHT) is commonly used in cosmetic formulations as an antioxidant. In addition to personal care products and makeup, it is also widely used in plastics and foods. BHT (or 2,6-di- tert -butyl- p -cresol) is a white to yellowish crystalline solid that prevents the oxidation of fats and oils, and helps to extend a product

  • butylated hydroxytoluene (bht) in food - uses, safety, toxicity

    Butylated Hydroxytoluene (BHT) In Food - Uses, Safety, Toxicity

    In two men, excretion of a single oral dose of 40 mg/kg [14C] butylated hydroxytoluene (BHT) was 50% in the first 24 hours, followed by slower excretion for the next 10 days. In total, 63-67% of the dose was excreted in the urine after 10 days.

  • pharmacokinetics of a novel butylated hydroxytoluene

    Pharmacokinetics of a novel butylated hydroxytoluene

    Mice, rats, dogs, and monkeys were given a single 50 mg/kg oral dose of [14C]LY256548. Plasma levels of radioactivity and LY256548 were determined, as was the excretion of radioactivity. Peak plasma levels of LY256548 occurred prior to those of radioactivity in mice, dogs, and monkeys, but were coincident in rats. The Cmax of LY256548 in rats, mice, dogs, and monkeys was 0.17, 0.30, 0.04, and

  • provisional peer-reviewed toxicity values for butylated

    Provisional Peer-Reviewed Toxicity Values for Butylated

    1 Butylated Hydroxytoluene . PROVISIONAL PEER-REVIEWED TOXICITY VALUES FOR BUTYLATED HYDROXYTOLUENE (CASRN 128-37-0) BACKGROUND . A Provisional Peer-Reviewed Toxicity Value (PPRTV) is defined as a toxicity value derived for use in the Superfund Program. PPRTVs are derived after a review of the relevant

  • 707. butylated hydroxytoluene (bht) (who food additives

    707. Butylated hydroxytoluene (BHT) (WHO Food Additives

    The disposition of single oral doses of BHT was compared in man and rat. A single oral dose of 0.5 mg/kg body weight of BHT was ingested by 7 healthy male volunteers after fasting overnight. Blood samples were taken after 0, 15, 30, 45, 60, 75, 90, 120, 150, 180 and 240 minutes. Total urine and faeces were collected for 2 days.

  • the metabolism of 2,6-di-tert.-butyl-4-hydroxymethylphenol

    The metabolism of 2,6-di-tert.-butyl-4-hydroxymethylphenol

    Abstract. 1. A single oral dose of [14 C]Ionox 100 to rats is almost entirely eliminated in 11 days: 89·1–107·2% of the 14 C is excreted and 0·29±0·02% of the dose is present in the carcass plus viscera after removal of the gut.

  • butylated hydroxytoluene (bht) (iarc summary & evaluation

    Butylated Hydroxytoluene (BHT) (IARC Summary & Evaluation

    In mice, a single intraperitoneal dose or feeding of butylated hydroxytoluene can cause pulmonary alveolar cell necrosis and proliferation. Butylated hydroxytoluene also induces proliferation of smooth endoplasmic reticulum in rat-liver cells, leading to hepatomegaly.

  • safety data sheet bht - sasol

    SAFETY DATA SHEET BHT - Sasol

    Chemical Name LD50 Oral LD50 Dermal LC50 Inhalation Butylated Hydroxytoluene >6,000 mg/kg (Rat) >2000 mg/kg (Rat) Chronic toxicity Repeated dose toxicity Repeated oral exposure of laboratory animals (rats and mice) at doses greater than 25 mg/kg/day resulted in growth depression and functional and histological

  • quantitative identification of and exposure to synthetic

    Quantitative identification of and exposure to synthetic

    Disposition of single oral doses of butylated hydroxytoluene in man and rat Single oral doses of 200, 63 or 20 mg BHT/kg body weight were administered to rats and a single oral dose of 0.5 mg

  • the urinary excretion of tritiated butylated hydroxyanisole

    The urinary excretion of tritiated butylated hydroxyanisole

    Disposition of single oral doses of butylated hydroxytoluene in man and rat. Verhagen H, Beckers HH, Comuth PA, Maas LM, ten Hoor F, Henderson PT, Kleinjans JC. Food Chem Toxicol, 27(12):765-772, 01 Dec 1989 Cited by: 6 articles | PMID: 2606406

  • gastric retention and delayed absorption of a large dose

    Gastric retention and delayed absorption of a large dose

    1. After a single oral dose of 800 mg/kg of butylated hydroxytoluene to rats, the plasma concentration of 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone (BHT quinone methide), an active metabolite of BHT, reached a maximum 18 h after dosing.