• disulfiram - wikipedia

    Disulfiram - Wikipedia

    The synthesis of disulfiram, originally known as tetraethylthiuram disulfide, was first reported in 1881. By around 1900, it was introduced to the industrial process of Sulfur vulcanization of rubber and became widely used.

  • disulfiram (tetraethylthiuram disulfide) | aldehyde

    Disulfiram (Tetraethylthiuram disulfide) | Aldehyde

    Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. - Mechanism of Action & Protocol.

  • disulfiram (tetraethylthiuram disulfide) in the treatment

    Disulfiram (Tetraethylthiuram Disulfide) in the Treatment

    Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases Antibiotics (Basel) . 2019 May 30;8(2):72. doi: 10.3390/antibiotics8020072.

  • tetraethylthiuram disulfide (disulfiram)

    TETRAETHYLTHIURAM DISULFIDE (DISULFIRAM)

    tetraethylthiuram disulfide: product identification. cas no. 97-77-8: einecs no. 202-607-8: formula [(c 2 h 5) 2 ncs 2-] 2: mol wt.

  • disulfiram | anesthesia key

    Disulfiram | Anesthesia Key

    Disulfiram (tetraethylthiuram disulfide [CASRN 97-77-8], or Antabuse) is an antioxidant industrial chemical produced since 1881 for the vulcanization of rubber. Introduced in the 1930s into clinical medicine as a vermicide and scabicide, it has been used since 1951 as a drug in the treatment of alcoholism.

  • disulfiram--breakthrough drug for lyme and other tick-borne

    Disulfiram--breakthrough drug for Lyme and other tick-borne

    Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases. Antibiotics (Basel) . 2019 May 30;8(2). pii: E72. doi: 10.3390/antibiotics8020072.

  • disulfiram--breakthrough drug for lyme and other tick-borne

    Disulfiram--breakthrough drug for Lyme and other tick-borne

    Disulfiram (Tetraethylthiuram Disulfide) in the Treatment of Lyme Disease and Babesiosis: Report of Experience in Three Cases. Antibiotics (Basel) . 2019 May 30;8(2). pii: E72. doi: 10.3390/antibiotics8020072.

  • disulfiram | drug | britannica

    Disulfiram | drug | Britannica

    …Erik Jacobsen of Denmark, uses disulfiram (tetraethylthiuram disulfide, known by the trade name Antabuse). Normally, as alcohol is converted to acetaldehyde, the latter is rapidly converted, in turn, to harmless metabolites. However, in the presence of disulfiram—itself harmless—the metabolism of acetaldehyde is blocked.

  • thiuram disulfide - wikipedia

    Thiuram disulfide - Wikipedia

    The tetraethyl derivative, known as disulfiram, is commonly used to treat chronic alcoholism. It produces an acute sensitivity to alcohol ingestion by blocking acetaldehyde dehydrogenase conversion of acetaldehyde leading to a higher concentration of the aldehyde in the blood producing symptoms of a severe hangover .

  • tetraethylthiuram disulfide (antabuse) inhibits the human

    Tetraethylthiuram disulfide (Antabuse) inhibits the human

    Tetraethylthiuram disulfide (Antabuse, disulfiram) and its reduction product diethyldithiocarbamate inhibit many metalloprotein oxygenases and have a lipid/H2O partition coefficient and high binding constant for metal ions, favoring selective toxicity to the malaria parasite.

  • using disulfiram to treat alcoholism and alcohol abuse

    Using Disulfiram to Treat Alcoholism and Alcohol Abuse

    The History of Disulfiram. In the 1930s, workers in the rubber industry noticed they were becoming sick after drinking alcohol. These workers were dealing with tetraethylthiuram disulfide. In the later 1940s, when disulfiram was given in a study on stomach ailments, those who consumed alcohol also became ill.

  • disulfiram toxicity: practice essentials, pathophysiology

    Disulfiram Toxicity: Practice Essentials, Pathophysiology

    Disulfiram (tetraethylthiuram disulfide [TETD]) has been used for more than 50 years as a deterrent to ethanol abuse in the management of alcoholism. Approximately 200,000 alcoholics take disulfiram, or Antabuse, regularly in the United States. Disulfiram has also been proposed as a deterrent to cocaine abuse, and several studies have suggested

  • is disulfiram (antabuse) the new cure for lyme disease

    Is Disulfiram (Antabuse) the New Cure for Lyme Disease

    Tetraethylthiuram disulfide, also known as disulfiram and branded Antabuse, is an anti-alcoholism treatment that literally makes a patient have a massive hangover if he or she drinks any alcohol. Disulfiram is known to also have antibiotic properties.