Biological impact of phthalates | Request PDF
Request PDF | Biological impact of phthalates | Esters of phthalic acid are chemical agents used to improve the plasticity of industrial polymers. Their ubiquitous use in multiple commercial
Biological impact of phthalates
overall potential effects on biological systems and allows for comparison between phthalates with respect to each individual biological end point. 2. Materials and methods 2.1. Cytotoxicity MVLN cells were propagated in DMEM/F-12 media containing 10% FBS at 37 C, 5% CO2. Cytotoxicities of phthalates were determined by exposing 8×104 MVLN cells
Phthalates: The Everywhere Chemical
your healthcare provider to use phthalate-free tubing and medical bags especially for procedures such as blood transfusions and dialysis. What negative health effects have phthalates been shown to have in laboratory animals? Very few studies have examined the health effects of phthalates on humans. In lab animals, phthalate exposure
Phthalates in food and medical devices | Request PDF
Request PDF | Phthalates in food and medical devices | Phthalates are ubiquitous environmental chemicals with a broad range of potential adverse health effects. Exposure pathways include air
Metabolism of phthalates in humans | Request PDF
Request full-text PDF. Phthalates have short biological half-lives (<24h) To understand and to treat the adverse effects of phthalates on human health, it is essential to expand the
Biological impact of phthalates - ScienceDirect
Highlights Investigated the biological impact of phthalates DEHP, DEP, DBP and BBP. Phthalates differing in physicochemical properties have similar endpoints. Phthalates simultaneously affect multiple cellular targets. Demonstrated the need for the simultaneous assessment of multiple endpoints.
APPENDIX E1 MODELING CONSUMER EXPOSURE TO PHTHALATE ESTERS
work was performed at the request of the Chronic Hazard Advisory Panel (CHAP) on phthalates and phthalate substitutes. These comments are those of the CPSC staff, have not been reviewed or approved by, and may not necessarily
Cumulative risk assessment of phthalates in edible vegetable
Both phthalates were detected in four major edible vegetable oil sources. The phthalate with the highest detection rate was DBP (13.48%), followed by DEHP (7.78%). The results of the cumulative risk assessment showed that the hazard indices of these two phthalates in edible vegetable oils were less than 1, except in soybean oil.
Urinary Phthalates and Increased Insulin Resistance
Early life exposure to phthalates has been associated with a variety of adverse effects, particularly involving endocrine processes. 1, 8 Although an exploratory, cross-sectional analysis of the 1999–2002 US NHANES did not identify significant associations of urinary phthalate metabolites with BMI among children, 9 other analyses, including an analysis of 2003–2008 NHANES data, have found
Antiandrogenic effects of dibutyl phthalate and its
ABSTRACT Developmental toxicity following administration of dibutyl phthalate (DBF) and its major metabolite, monobutyl phthalate (MBuP), by gavage was determined in Wistar rats. DBF on days 0–8 of pregnancy induced an increase in the incidence of preimplantation loss at 1250 mg/kg and higher and postimplantation loss at 750 mg/kg and higher.
Phthalates and other additives in plastics: human exposure
Concern exists over whether additives in plastics to which most people are exposed, such as phthalates, bisphenol A or polybrominated diphenyl ethers, may cause harm to human health by altering endocrine function or through other biological mechanisms.
A critical analysis of the biological impacts of plasticizers
Topics: bisphenol A, endocrine disruption, diethylhexyl phthalate, butyl benzyl phthalate, dimethyl phthalate, dibutyl phthalate
Human body burdens of chemicals used in plastic manufacture
2005 Biological monitoring of the five major metabolites of di-(2-ethylhexyl)phthalate (DEHP) in human urine using column-switching liquid chromatography-tandem mass spectrometry. J. Chromatogr.